Psychedelics are thought of as ‘mind-expanding’ drugs so it has commonly been assumed that they work by increasing brain activity, but surprisingly, we found that psilocybin actually caused activity to decrease in areas that have the densest connections with other areas. These hubs constrain our experience of the world and keep it orderly. We now know that deactivating these regions leads to a state in which the world is experienced as strange.
Confessions of an Opium-Seeker chronicles Nick Tosches’ attempt to find an opium den in the age of quick-fixes and connoisseur culture. I need to read some more of his work, the writing style sucked me into the article.